To elucidate the underlying mechanism by which HDAC11 induces EMT and renal fibrosis in the UUO model, we investigated the effect of HDAC11 inhibition on the phosphorylation of Smad3 (p-Smad3) and STAT3 (p-STAT3) in the kidney and cultured RTPCs. This evidence concerns the gene STAT3 and renal fibrosis.