HDAC11 and chronic kidney disease: Since IL-10 is a cytokine with potent anti-inflammatory properties and administration of IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease,(Mu et al. 2005) increased expression of IL-10 by HDAC11 inhibition may confer an anti-fibrotic effect via suppressing renal inflammation in the kidney following injury.