A previous study had revealed that HDAC6 plays a critical role in regulating protein aggregation, axonal transport, and inflammation, which are associated with disease such as Gaucher disease, Huntington’s disease, and other neurodegenerative disodres21.One study reported that an HDAC6 inhibitor modulated molecular chaperone proteins such as HSP90 and HSP70, influencing the folding of Peripheral Myelin Protein 22 (PMP22) protein in Charcot-Marie-Tooth disease. Here, HDAC6 is linked to Charcot-Marie-Tooth disease.