OAS1 and COVID-19: For example, the cis-irQTL rs10774671 (G>A) in OAS1 disrupts a 3′ splice acceptor site (predicted by SpliceAI30), changing expression from the antiviral isoform OAS1-p46 to the less effective OAS1-p42, potentially modulating COVID-19 severity by altering how OAS1 splicing influences white blood cell counts39,54.