To obtain methylated gene data, the Taiwan Biobank 2016–2017, 65 biological risk genes, and the GSE113725 dataset were intersected, revealing 5 genes and 14 CpG sites potentially associated with depression (IL2RB-cg02238178, IL2RB-cg11558856, IL15RA-cg03108606, IL15RA-cg07796897, IL15RA-cg08676905, IL6R-cg25853020, IL6R-cg09257526, IL6R-cg04715245, FTL-cg04385818, FTL-cg03039974, ZNF614-cg09503196, ZNF614-cg25776555, ZNF614-cg03293882, and ZNF614-cg15684917). This evidence concerns the gene IL6R and major depressive disorder.