In addition, elevated DNAm GDF15 was uniquely associated with lower levels of nearly all primary brain regions and greater rates of atrophy in three primary regions following FDR correction, including steeper total brain (βGDF15 = −0.40 [0.10, p < 0.001]) and gray matter (βGDF15 = −0.23 [0.09, p = 0.007]) declines, as well as an increase in SPARE‐AD (βGDF15 = 0.02 [0.004, p < 0.001]) score. The gene discussed is GDF15; the disease is Alzheimer disease.