In addition, greater plasma GDF15 was associated with declines in total brain (βs = −0.458 [0.07, p < 0.001]), gray matter (βs = −0.248 [0.05, p < 0.001]), and white matter (βs = −0.408 [0.04, p < 0.001]) volumes and increases in SPARE‐AD (βs = 0.014 [0.002, p < 0.001]), SPARE‐BA (βs = 0.046 [0.014, p = 0.001]) and CSF ventricle volume (βs = 0.306 [0.037, p < 0.001]; Table 1). This evidence concerns the gene GDF15 and Alzheimer disease.