We next used data from the ARIC study to determine whether midlife DNAm CRP and GDF15 measures were associated with 25‐year dementia risk (n = 2606; M age: 57.0 [5.7 SD]; 42.0% female; median follow‐up = 20.2 years; IQR = 14.8–26.6 years; 585 dementia cases). The gene discussed is GDF15; the disease is dementia.