Although higher levels of GDF15 protein have also been linked to poor brain health and dementia risk (Isik et al. 2024; Walker et al. 2024; Walker, Chen, et al. 2023), less is known about the extent to which an epigenetic indicator of long‐term GDF15 exposure (DNAm GDF15) relates to adverse neurocognitive outcomes (Gadd et al. 2024). This evidence concerns the gene GDF15 and dementia.