IAPP and metabolic dysfunction-associated steatohepatitis: In the Gubra–amylin liver nonalcoholic steatohepatitis diet–fed ob/ob mouse model of MASH, increases in the SAM/SAH ratio, upregulation of fibrosis-related genes, and alterations in H3 histone methylation were observed, similar to those seen in the CDAHFD-fed MASH model.