To complement the CDAHFD–MASH model, we also examined a second model, the Gubra–amylin nonalcoholic steatohepatitis (GAN) diet–fed ob/ob mouse model, a modification of the traditional trans–fatty acid–rich amylin liver nonalcoholic steatohepatitis diet in which Primex shortening is replaced by an equal amount of palm oil (14). The gene discussed is IAPP; the disease is metabolic dysfunction-associated steatohepatitis.