Regarding risk factors for FN, these guidelines mention older age (≥ 65 years), advanced cancer, history of open wound surgery, history of FN, no use of G-CSF or prophylactic antimycotics, history of chemotherapy or radiotherapy, presence of neutropenia or bone marrow infiltration of tumor cells, poor PS, decreased kidney function, decreased liver function, cardiac diseases, and HIV infection [14, 19, 20]. Here, CSF3 is linked to Decreased total neutrophil count.