Regarding risk factors for FN, these guidelines mention older age (≥ 65 years), advanced cancer, history of open wound surgery, history of FN, no use of G-CSF or prophylactic antimycotics, history of chemotherapy or radiotherapy, presence of neutropenia or bone marrow infiltration of tumor cells, poor PS, decreased kidney function, decreased liver function, cardiac diseases, and HIV infection [14, 19, 20]. The gene discussed is CSF3; the disease is cancer.