FN1 is known to play a role during tumor immune evasion by regulating extracellular matrix (ECM) remodeling [88, 89].Finally, when comparing ASEs detected in melanoma versus 19 normal tissues from ENCODE, we found that cancer cells contained 787 atypical ASEs (Fisher’s exact test, P = 4.748e-20) (Fig. 8E). Here, FN1 is linked to melanoma.