SENP1-mediated deSUMOylation of nuclear factor κB essential modulator, β-catenin, peroxisome proliferator-activated receptor γ, and the target of Myb1 in microglia antagonizes the inflammatory response and cognitive impairment induced by IH [29, 30, 67, 68]. Here, SENP1 is linked to isolated hemihyperplasia.