While the functional consequence of rs7018644 is currently unknown and we did not find direct evidence linking this SNP to altered IGFBPL1 expression or to breast cancer risk, we note that IGFBPL1 belongs to insulin-like growth factor binding proteins (IGFBPs) family, which are known to regulate the functions of insulin-like growth factors. This evidence concerns the gene IGFBPL1 and breast carcinoma.