Pompe disease (Glycogen Storage Disease type II, α-glucosidase deficiency), and Mucopolysaccharidosis Type I (MPS-I) (Hurler, Hurler/Scheie or Scheie Disease) are caused by a deficiency of α-glucosidase and alpha-L-iduronidase, respectively [2]. Here, IDUA is linked to mucopolysaccharidosis type 1.