Hepatic histology revealed liver parenchymal heterogeneity with fibrosing hepatopathy (AI F3/F4 METAVIR score), acute cholangiolitis, biliary duct dystrophy, ductular neogenesis without ductopenia, and intracytoplasmic AAT globules, without steatosis or significant inflammation (Fig. 1D). This evidence concerns the gene SERPINA1 and Decreased liver function.