CXCL8 and infection: Additionally, while IL-8 is already recognized for its clinical relevance, MDSCs may provide additional insights into immune dysregulation states Moreover, the rapid mobilization of dysfunctional neutrophils (induced by the IL-8 rise) as well as monocytes with low HLA-DR expression may underlie a combined innate-adaptative immunoparalysis that can increased infection susceptibility in PT patients [49].