NLRP3 and cardiac arrhythmia: Acute exposure of IL-1β to a murine cardiomyocyte cell line activates NLRP3-dependent pathways and upregulates CaMKII/RyR2 axis, sensitizing cardiomyocytes to spontaneous Ca2+ fluxes and electrophysiological alterations [103] These findings highlight the central role of NLRP3 in arrhythmogenesis, yet its contribution to radiation-induced arrhythmias remains unexplored.