EGFR and bone metastasis: Other factors, including age, tumor location, bone metastasis, brain metastasis, lung metastasis, liver metastasis, pathological type, EGFR mutation status, surgery, radiotherapy, EGFR-TKI treatment, and ICIs treatment, did not show a significant prognostic impact on OS in the multivariate analysis (P > 0.05) (Table 4).