We further found that the GLIS3 rs7034200C/A polymorphism had a significant effect on fasting and 2-hour glucose concentrations in the OGTT during 24–28 weeks of pregnancy, HDL-C, fasting insulin, HOMA-IR, TOS, OSI, TAC, and TG/HDL-C ratio among GDM and/or control pregnant women. The gene discussed is GLIS3; the disease is gestational diabetes.