GLIS3 and gestational diabetes: However, the AA/TT combined genotype of the GLIS3 rs7034200C/A and ADRB3 rs4994T/C polymorphisms was associated with an elevated risk of GDM, with the CC/TT combined genotype as a reference (OR = 1.708, 95% CI: 1.191–2.450; P = 0.004).