PIK3CA and Venous malformation: Further studies revealed somatic GoF TEK variants (mainly L914F) in ~50% sporadic venous malformations, and in PIK3CA (mainly hotspot variants E542K, E545K, and H1047R) in 20% (Limaye et al, 2009b; Soblet et al, 2013; Limaye et al, 2015; Castel et al, 2016; Castillo et al, 2016).