Abbreviations: eGFR – estimated Glomerular Filtration Rate, UACR – Urine-Albumin-Creatinine-ratio, ANCA – anti-neutrophilocyte-cytoplasmic-antibody, ADPKD – autosomal dominant polycystic kidney disease, RAS – renin-angiotensin system, SGLT2i-sodium-glucose co-transporter 2 inhibitor. Here, REN is linked to autosomal dominant polycystic kidney disease.