When setting either the area or the perimeter of visceral adipocytes in participants with obesity as a dependent variable, a significant interaction was found, using the serum adiponectin/leptin ratio (R2 = 0.451, P = 0.009; R2 = 0.525, P = 0.003, respectively) as an independent variable (Table 3). Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.