When setting the area of subcutaneous adipocytes in individuals without obesity as a dependent variable, 2 models with significant interactions were observed, using the serum adiponectin/leptin ratio (R2 = 0.377, P = 0.044) (model 1) or the serum adiponectin/leptin ratio and systolic blood pressure (SBP) (R2 = 0.628, P = 0.019) (model 2) as independent variables (Table 3). The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.