TREM2 and Ureteral obstruction: Notably, in cases of renal injury, particularly those induced by unilateral ureteral obstruction (UUO) or ischemia‒reperfusion (IRI) injury, TREM2 deficiency exacerbates renal damage by promoting macrophage polarization toward the M1 proinflammatory phenotype via the JAK‒STAT pathway, ultimately reducing cell viability50.