FKBP5 and autoimmune polyendocrinopathy: To further clarify the mechanism of FKBP5 in regulating macrophage polarization at the maternal–fetal interface involved in aPLs-induced pathological pregnancy of placental origin, we used anti-β2GP1 antibody to construct OAPS in FKBP5 knockout mice (Fkbp5-/- + APS group) and control mice (WT + APS group), respectively.