PHLPP1 and colorectal cancer: For example, in fat tissues FKBP5 synergizes with PHLPP to activate the PI3K/AKT pathway, driving PPARγ transcriptional activity and preadipocyte maturation54, whereas in colorectal cancers FKBP5 promotes NF-κB nuclear translocation through inhibition of IκBα degradation, which in turn upregulates MMP-2/MMP-9 expression and accelerates metastasis17.