As loss of E-cadherin, a marker of epithelial–mesenchymal transition (EMT), has been associated with an increase in (OSCC) tumour cell proliferation in mice studies31 and malignant transformation in oral cavity lesions in human samples32, we examined whether co-culture with adipocytes affects E-cadherin levels in OTSCC cells. Here, CDH1 is linked to neoplasm.