APOE and memory: APOE ε4 was not significantly related to memory decline (β[CI] = −0.035[−0.10, 0.02], t(df) = −0.95(3296), p = 0.34) (Fig. 4a) but the relationship between APOE status and memory change increased with age (βw = -0.008, edf = 1, p = 0.03), that is, APOE ε4 carriers showed less memory decline until ≈60 years of age, and more memory decline thereafter (Fig. 4b).