APOE and hippocampal atrophy: However, at an uncorrected level, APOE ε4 was associated with a higher degree of hippocampal atrophy with increasing age (βwl = −0.011, edf = 1, punc = 0.01; βwr = −0.009, edf = 1, punc = 0.04, respectively) (Supplementary Fig. 4).