APOE ε4 was associated with steeper left and right hippocampal atrophy (βl[CI] = −0.135[−0.20,−0.07], t(df) = −4.2(3228.1), pFDR = 0.004; βr[CI] = −0.138[−0.20,−0.07], t(df) = −4.1(3261.1), pFDR = 0.003) as well as right amygdala atrophy (β[CI] = −0.154[−0.22,−0.09], t(df) = −4.7(3249), pFDR < 0.001) (Fig. 5a). Here, APOE is linked to hippocampal atrophy.