GCKR and type 2 diabetes mellitus: GWAS revealed prominent signals at known loci for T2D (TMEM18 and LINC00971), CVD (ARHGAP22, MYO1B, LINC02056, and MOCS1), lipid traits (GCKR, APOA5-APOC3 loci for TG, and APOE, CETP, LDLR for LDL-C, HDL-C, and TC), and suggestive signals for FBS and HbA1c (TSPAN2, SPAG17, CASR, and FTO) (Supplementary Fig. S4 and Table S12).