Thus, we further investigated the mechanisms by which gomesins target melanoma cells using various cell death inhibitors (Fig. S2A), including necrostatin-1 (necroptosis inhibitor), ferrostatin-1 (ferroptosis inhibitor), VX-765 (caspase 1/4 inhibitor, pyroptosis) and z-VAD FMK (pan-caspase inhibitor). Here, CASP1 is linked to melanoma.