We selected the best candidate from a battery of shRNAs for each of these genes (Fig. 6A) and confirmed through viability assay that individually knocking down ST3GAL5, B4GALT5 or UGCG diminished the cytotoxicity of both AgGom and HiGom in melanoma cells (Fig. 6B). The gene discussed is ST3GAL5; the disease is melanoma.