COMMD3 and ovarian carcinoma: To systematically identify key RNA processing regulators involved in the progression of ovarian carcinoma (OC), we performed a genome-wide gene knockout screening based on a previously identified OC-promoting transcriptional readthrough (TRT) event caused by dysregulated transcriptional termination of tumor suppressor gene COMMD3 which leads to the fusion of COMMD3 with downstream oncogene BMI1 [27].