SIRT1 and amyotrophic lateral sclerosis: These included edaravone, a redox-scavenging molecule that is FDA approved for ALS [30–32], the combination of TUDCA and PB, which targets ER stress and Bax-driven mitochondrial cytochrome c release [33, 34], resveratrol, a SIRT1 activator that enhances mitochondrial biogenesis and quality control [35, 36], glutathione, an essential antioxidant, and creatine, a high-energy phosphate storage to replenish ATP in cells [37].