Given the tight interaction within HNRNPA2B1 and immune infiltrating cells enrichment, the co-culture system was built using NSCLC cells (A549) and activated CD8+ T cells to investigate the role of HNRNPA2B1 on CD8+ T cells’ antitumor response (Fig. 2A). The gene discussed is HNRNPA2B1; the disease is non-small cell lung carcinoma.