Results showed that CD8+ T cells secreted lower level of IFN-γ (Fig. 2B), TNF-α (Fig. 2C), TNF-α (Fig. 2E), Granzyme-B (Fig. 2F) when co-cultured with NSCLC cells transfected by HNRNPA2B1 overexpression. The gene discussed is HNRNPA2B1; the disease is non-small cell lung carcinoma.