Furthermore, HNRNPA2B1 targeted the LDHA mRNA m6A modified site to enhance LDHA mRNA stability and lactate accumulation, thereby assisted NSCLC cells to evade CD8+ T antitumor immunity and reduced IFN-γ secretion by CD8+ T. Furthermore, IFN-γ could stimulate ferroptosis of NSCLC cells. The gene discussed is CD8A; the disease is non-small cell lung carcinoma.