Dual CAR‐T cells, with two distinct CAR molecules, target tumor‐specific antigens and TAMs,[98] while Tandem CARs (TanCARs) combine binding domains for tumor antigens (e.g., HER2 or EGFR) and M2‐like macrophage markers (e.g., CD206), enhancing CAR‐T cell activation and TAM elimination, improving efficacy.[99, 100] Trifunctional CAR‐T cells further target tumor heterogeneity by adding macrophage markers to prevent tumor escape. The gene discussed is EGFR; the disease is neoplasm.