These models enable the examination of immune cell behavior in an immunocompetent host, revealing TAMs' role in regulating CAR‐T cell responses.[113] Researchers can assess CAR‐T cell effectiveness by tracking tumor progression, CAR‐T cell persistence, and immune checkpoint marker expression.[113] Additionally, the impact of TAM depletion, such as using CSF1R inhibitors, on CAR‐T cell activity and tumor response can be evaluated.[114]. This evidence concerns the gene CSF1R and neoplasm.