IFNG and neoplasm: Some researchers have tried to shift exogenous cytokine IFN‐γ, which causes M1 polarization, or just using vectors to amplify the production of M1 cytokines (GM‐CSF) locally, which have been shown to support the inhibition rather than the progression of tumor growth in TAM phenotypes.[85] Cytokine modulation to reprogram TAMs toward an M1 phenotype shows promise, but challenges include controlling local cytokine production and ensuring long‐term stability without exacerbating inflammation or tissue damage.