Many of these downregulated proteomic cargoes in melanoma sEVs, including collagens (COL1A1, COL3A1, COL6A1–A3, and COL14A1), matrix-associated proteoglycans (DCN, LUM, FMOD, OGN, and PRELP), and structural regulators (TNXB and PCOLCE), are key components of ECM organization and tensile strength (58). Here, COL14A1 is linked to melanoma.