Furthermore, the upregulation of key melanoma-specific cargoes: LGALS9 (p = 0.029), CD3D (p = 0.097), and CD38 (p = 0.14) in the blood plasma sEVs of melanoma patients was noted in contrast to healthy donors (Fig. 9, A and B and Supplemental Fig. S13). This evidence concerns the gene LGALS9 and melanoma.