Many of these downregulated proteomic cargoes in melanoma sEVs, including collagens (COL1A1, COL3A1, COL6A1–A3, and COL14A1), matrix-associated proteoglycans (DCN, LUM, FMOD, OGN, and PRELP), and structural regulators (TNXB and PCOLCE), are key components of ECM organization and tensile strength (58). This evidence concerns the gene LUM and melanoma.