To determine the abundance of the selected proteomic signatures in the sinuses of the LN, we employed pathologist-guided MxIF analysis to compare fluorescence intensity between negative melanoma SLNs and control LN, and we detected significantly higher levels of CD38 (p = 0.0003), LGALS9 (p = 0.027), and TNC (p = 0.012) in the sinuses of melanoma patients (Fig. 8). This evidence concerns the gene LGALS9 and melanoma.