RHO and Abnormal retinal morphology: The ciliary protein interactome appeared abnormal in all RGPRIP1 variant organoids and was sufficient to perturb the transport of rhodopsin and L/M-opsin to the OS of photoreceptors, a phenotype that has been described in RPGRIP1 null murine models (Zhao et al., 2003) and other retinal disease organoid models (Bocquet et al., 2023; Chahine Karam et al., 2022; West et al., 2022).