People with one or more APOE-ε4 allele were younger (66.56 years compared to 69.02 years), had higher proportion of very mild cognitive impairment (23 % compared to 16 %), lower MMSE (28.67 compared to 28.99), and higher Aβ burden (29.57CL compared to 11.33CL). This evidence concerns the gene APOE and Cognitive impairment.