Previous studies have reported that the PI3K/AKT pathway is a major downstream pathway of TIMP1, with TIMP1 activating FAK/PI3K/AKT signaling to promote thyroid cancer progression.[29] Consistent with this, analysis of pathway‐related proteins showed that phosphorylation of FAK, PI3K, and AKT was markedly reduced in the sh‐SOX9+vector group but restored in the sh‐SOX9+TIMP1 group (Figure S5A,B, Supporting Information). This evidence concerns the gene TIMP1 and thyroid cancer.