Both tumor weight and volume were significantly reduced in the NPs@si‐SOX9/CL and iRGD NPs@si‐SOX9/CL groups compared with PBS, with more pronounced suppression observed in the NPs@si‐SOX9/CL+L and iRGD NPs@si‐SOX9/CL+L groups. This evidence concerns the gene SOX9 and neoplasm.