Among the other potentialpre-sensitizing drugs were CDK inhibitors, a CHEK1 inhibitor, and OTS167, whichtargets MELK and has been reported to inhibit FLT3 protein translation andsynergize with the FLT3 inhibitor gilterinib in FLT3-ITD-mutated AML (35). Here, CHEK1 is linked to acute myeloid leukemia.