Among these, LYN and FES are expressed in MOLM-13 andMV4-11 and play key roles in oncogenic FLT3 downstream signaling (46,47).In primary AML cells, meisoindigo demonstrated strong synergy with quizartinib inboth samples, with synergy scores even higher than in the cell lines. The gene discussed is FES; the disease is acute myeloid leukemia.