FLT3 and acute myeloid leukemia: However, most drug combinations thatdemonstrated synergistic effects in MOLM-13 cells also showed synergy in thehomozygous FLT3-ITD+/+ MV4-11 cell line, as well as in FLT3-ITD-mutatedprimary AML patient samples with a high FLT3-ITD variant allele frequency,indicative of a homozygous mutation.