In patients who tested positive for IgG-Fn, significant differences were observed for ypT (tumor depth) (0–2 vs. 3/4, p < 0.05), ypN (lymph node metastasis) (0 vs. 1–3, p = 0.02), and ypStage (TNM classification; 0-II vs. III/IV, p < 0.001), indicating that their condition was more advanced. Here, FN1 is linked to metastatic malignant neoplasm in the lymph nodes.