RAPGEF5 and cancer: Genes C-X-C motif chemokine ligand 14 (CXCL14), Interleukin 1 receptor like 1 (IL1RL1), Kinase insert domain receptor (KDR), Nuclear receptor subfamily 1 group D member 1 (NR1D1), Prolyl 3-hydroxylase 2(P3H2), PRDM16 divergent transcript (PRDM16-DT/ LINC00982) and Rap guanine nucleotide exchange factor 5 (RAPGEF5) have all been reported to be associated with malignancies [41,45,47–51].