Waldenström macroglobulinemia (WM), a clinically significant subset of LPL, is defined by the concomitant presence of serum monoclonal immunoglobulin M (IgM) paraproteinemia and bone marrow infiltration by clonal lymphoplasmacytic cells, with approximately 95% of LPL cases meeting the diagnostic criteria for WM [1, 2]. Here, LPL is linked to Waldenstrom macroglobulinemia.