The evaluation of proteins associated with AD development in young DS individuals and in DSAD comparison with age-matched controls supported the shared alteration of GFAP, SLC1A3, DNM1L, VDAC1-3, GAP43, MAG, SYP, ATP6V1G2, and TXN, among others (Fig. 3E.1,2). Here, DNM1L is linked to Alzheimer disease.