Therefore, considering the potency of these important hits on EGFR inhibition, studying their cytotoxic potential on overexpressing‐EGFR NSCLC cell lines NCI‐H292 (EGFRwt), PC‐9 (EGFRL858R), and NCI‐H1975 (EGFRL858R/T790M) would provide information on the convergence of enzymatic and phenotypic assays. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.