EGFR and non-small cell lung carcinoma: On this basis, the present work focuses on the evaluation of two synthetic acrylamide quinoxaline derivates LASSBio‐1971 (1) and LASSBio‐1974 (2) (Figure 2) to study, in phenotypic assays, their comparative cytotoxicity against NSCLC cell lines, apoptosis induction, EGFR inhibition, cell cycle behavior by flow cytometry, morphology by immunofluorescence microscopy, cell membrane permeability by PAMPA assay, and metabolic stability in rat liver microsomes (RLMs).