SAE1 and cancer: Previous reports havedemonstrated the role of UBA2 in various cancer types, whose expressionis positively correlated with the tumor promoter EZH2. SAE1 and UBA2 form a heterodimer that functionsas a SUMO-activating enzyme for the SUMOylation of proteins. Interestingly, analysis of the TCGA in ACC revealsthat UBA2 expression is positively correlated with SAE1, SUMO1, UBE2I(also known as UBC9), and TRIP6.