Previous reports havedemonstrated the role of UBA2 in various cancer types, whose expressionis positively correlated with the tumor promoter EZH2. SAE1 and UBA2 form a heterodimer that functionsas a SUMO-activating enzyme for the SUMOylation of proteins. Interestingly, analysis of the TCGA in ACC revealsthat UBA2 expression is positively correlated with SAE1, SUMO1, UBE2I(also known as UBC9), and TRIP6. Here, UBE2I is linked to adrenal cortex carcinoma.