This classification considersvascular invasion for both diagnostic and prognostic purposes, incorporatingthe mitotic count and Ki-67 labeling indexfor risk stratification. Molecular studiesof adrenocortical carcinomas have identified somatic variants, methylome,and microRNA expression profiles to classify, predict prognosis, andidentify new therapeutic targets., Thus, ourunderstanding of the molecular pathogenesis of adrenocortical diseases,particularly adrenocortical carcinomas, has made significant progressin recent years due to the application of high-throughput molecularanalysis. The gene discussed is MKI67; the disease is adrenal cortex carcinoma.