In agreementwith our analysis’s identification of downregulationof the ABLIM1 protein in ACC, a microarray analysis of ACCs and ACAsalso identified ABLIM1, which was validated by qPCR, as significantlydownregulated in ACCs compared to ACAs. The localization of ABLIM1 to 10q25, a region frequentlydeleted in human cancers that contains several tumor suppressor genes,identified it as a candidate for a tumor suppressor in melanomas. Kwong & Chin proved that knockdown of the Ablim1 gene using RNAi enhances invasionin vitro. Here, ABLIM1 is linked to cancer.