AKT1 and neoplasm: It has been previously detected in aldosterone-producingadenomas., The upregulation of PCP4 in aldosterone-producinghuman adenomas promotes growth via the AKT and AMPK pathways, andPCP4 mRNA expression level was positively correlated with tumor sizein APAs. Interestingly, adrenals withPMAHw were significantly larger and had more nodules than those with ARMC5 wild-type presentations,, suggestingthat PCP4 may be related to nodule size in PMAH and to the ARMC5 mutation.