APOE and Alzheimer disease: Although APOE ε4/ε4 seemed to exhibit higher odds of AD pathology than APOE ε3/ε4 carriers, most confidence intervals for APOE ε3/ε4 and APOE ε4/ε4 genotypes overlapped, probably due to the small number of participants with the APOE ε4/ε4 genotype (Table S1).