However, the mean age at death in participants with AD pathology was higher in those with APOE ε2/εX (86.7, 95% CI = 83.6 to 89.8) and was progressively lower across APOE ε3/ε3, ε3/ε4, and ε4/ε4, with the lowest age at death among those with APOE ε4/ε4 (79.0, 95% CI = 74.8 to 83.2). Here, APOE is linked to Alzheimer disease.