Our scRNA‐seq analyses revealed significant increases in several IFN‐responsive transcripts including MX1, a type I IFN responsive gene implicated in antiviral responses and upregulated in AD microglia,63 as well as HLA‐DR, a class II major histocompatibility complex and AD risk gene that is also commonly induced by interferon signaling.64 Here, IFNA1 is linked to Alzheimer disease.