These findings align with established evidence demonstrating that ANS dysfunction correlates with cognitive decline severity6, 7 and contributes to CCH and VCI through recurrent, transient orthostatic hypoperfusion episodes,4, 5, 6, 7, 8 potentially mediated through ANS‐related neuropeptide dysregulation.8, 9, 43, 44. This evidence concerns the gene NPS and Mental deterioration.