LEP and obesity due to melanocortin 4 receptor deficiency: Key among these signals will be identifying those that enhance leptin signaling (leptin “sensitizers” [82]) and the governance of skeletal muscle mass, the pharmacologic regulation of which has already demonstrated favorable maintenance of lean mass during weight loss and enhanced adipose mass loss [83], effectively serving as weight‐loss “signal multipliers.” Ultimately, understanding obesity as a disease and how homeostasis of adipose mass can be altered and maintained will result not just in improved patient health, but also a better patient experience and quality of life.