SOD1 and metabolic dysfunction-associated steatotic liver disease: Although mitochondrial oxidative stress is a prevalent root cause for metabolic diseases, reliance on the antioxidation strategy (e.g., ROS scavenging or SOD mimicry) is inadequate for addressing disease‐specific pathological issues.[275] For instance, in NAFLD, the contradictory mechanisms of compensatory enhancement of mitochondrial β‐oxidation and lipid toxicity‐induced ROS bursts suggest that combined regulation of lipid metabolism by nanomedicines should be implemented.