In a high‐fat diet mouse model, treatment with P‐G3‐Chol (5) NPs in diet‐induced obese mice with established obesity resulted in a 15% reduction in body weight, a 45% reduction in fat mass, and a 50% reduction in the eWAT depot size, while improving glucose tolerance.[205] These examples demonstrate that the multifunctional design of nanocarriers can be specifically tuned for different pathological stages of obesity (such as fat browning disorders and central leptin resistance). This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.