AICAR's organoprotective properties manifest differentially across tissues: it reduces renal oxidative stress and inflammation while maintaining SIRT1 homeostasis during ischemic injury [216]; reverses neurobehavioral abnormalities and AMPK/SIRT1 deficits in chronic stress models [217]; and ameliorates obesity‐induced insulin resistance through SIRT1‐dependent pathways [218]. Here, PRKAA2 is linked to obesity due to melanocortin 4 receptor deficiency.