Its crucial role in stem cell maintenance is evidenced by studies showing that resveratrol‐mediated SIRT1 activation expands adult stem cell populations and extends lifespan in progeroid mouse models [57], while SIRT1 deficiency in hematopoietic stem cells accelerates aging phenotypes, leading to anemia and immunodeficiency [58]. This evidence concerns the gene SIRT1 and Immunodeficiency.