Cryptic chromosomal translocation t (11; 17) (p15; p13) generates the NUP98-PHF23 fusion protein, and this fusion protein significantly promotes oncogenesis during AML development (Reader et al., 2007; Wang et al., 2009; Gough et al., 2014; Katoh, 2015; Togni et al., 2015; Xu et al., 2016; Gough et al., 2017; Kundu et al., 2019; Hamamoto et al., 2025). The gene discussed is PHF23; the disease is acute myeloid leukemia.