E2F2 and breast cancer: Furthermore, Using TCGAnalyzeR, we analyzed the expression profiles of E2F genes in BC tumors and found a significant upregulation of E2F1, E2F2, E2F7, and E2F8, with log2 fold-change values of 2.09, 2.41, 2.94, and 3.49, respectively (Figures 4A–H).