Wong et al. also illustrated that IRF4 and NF-κB form a feed-forward regulatory loop that coordinately controls oncogenic transcription programs, with their binding sites being significantly enriched in SEs to directly modulate the expression of critical leukemia drivers including MYC, CCR4, and BIRC3, further promoting the ATL development (Wong et al., 2020). The gene discussed is CCR4; the disease is leukemia.