Targeted Gene Set Enrichment Analysis (GSEA), performed on 25 curated gene sets associated with canonical (SMADs-dependent) and non-canonical (TAK1-dependent) TGF-β signaling pathways, demonstrated significant upregulation of two key pathways in Tumor-infiltrating NK Cells (TINKs) compared to Liver-infiltrating NK Cells (LINKs):. Here, TGFB1 is linked to neoplasm.