Th2 cells secrete IL-4, IL-5 and IL-13, among which IL-5 and IL-13 have been shown to have a protective effect on atherosclerosis, and IL-13 can reduce the infiltration of macrophages in plaques by decreasing the expression of vascular cell adhesion molecule-1 (VCAM-1) (12). The gene discussed is IL5; the disease is atherosclerosis.